to its structure, SEMAX® represents a synthetic
analogue of the short fragment of Corticotropin, with no hormonal
activities: ACTH (4-7) Pro-Gly-Pro.(Met-Glu-His-Phe-Pro-Gly-Pro)
The preparation is in the form of white crystalline hygroscopic
powder, easily soluble in water. For clinical tests, SEMAX®
was used in the form of nose drops (0.1% colorless transparent
water solution with nipagin as conserving agent, in hermetically
sealed bottles of 3.0ml, with pipette covers ,
pH = 4.0 - 5.5)
intranasal application, 60-70% of SEMAX® is very
quickly absorbed from the nasopharyngeal mucous membrane
into the system circulation, thus as early as 1-5 minutes following
its instillation the drug is accumulated in liver, adrenal glands,
brain, heart, kidneys and skeletal muscles, which points to
good distribution in the tissues.
Peak concentrations are achieved after 60 min.
develops through the action of aminopeptidases and angiotensin-converting
enzyme to individual amino acids. Its half-life (t 1/2) is 4
therapeutic effect, after the application of a single
dose, is maintained up to 20 hours. It is very rapidly excreted
in urine via kidneys . Its half-life is : 0.4-5 minutes.